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《医学前沿(英文)》 2013年 第7卷 第4期 页码 499-505 doi: 10.1007/s11684-013-0296-9
Pancreatic fistula (PF) is the most frequent complication after distal pancreatectomy (DP). Prophylactic transpapillary pancreatic stenting (PTPS) has been proposed recently for the prevention of PF after DP. In this meta-analysis, a comprehensive search was performed in the PubMed, Embase, and Cochrane Library databases. Studies analyzing the results of PTPS in DP were considered eligible for this meta-analysis. The analyzed outcome variables included PF rate, postoperative morbidity, non-PF-related complications, mortality, operation duration, and hospital stay. Four studies with 200 patients were included in this review. Only one was a randomized controlled trial (RCT). The results showed that PTPS was associated with less PF formation (odds ratio, 0.45; 95% confidence interval [CI], 0.22–0.94; P = 0.03) and shorter hospital stay (mean difference, -6.31; 95% CI, -6.99 to -5.62; P<0.00001). There was no significant difference in terms of the other variables. In conclusion, current evidence indicates that PTPS could reduce PF incidence and hospital stay after DP, without increasing other complications or operative time. However, the evidence is not solid, because the single RCT conflicted with the other three retrospective reports. Thus, considering the limitation, more well-designed RCTs on this topic are needed in the future.
关键词: pancreatic fistula distal pancreatectomy pancreatic stent meta-analysis
Laparoscopic surgery for pancreatic lesions: current status and future
Taiping Zhang, Xiao Du, Yupei Zhao
《医学前沿(英文)》 2011年 第5卷 第3期 页码 277-282 doi: 10.1007/s11684-011-0147-5
关键词: minimally invasive surgery pancreatic surgery pancreatic neoplasm distal pancreatic lesions pancreatic fistula
Li Jiang, Deng Ning, Xiaoping Chen
《医学前沿(英文)》 2020年 第14卷 第3期 页码 251-261 doi: 10.1007/s11684-019-0727-3
关键词: pancreatic fistula pancreatic body and tail resection distal pancreatectomy
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 430-435 doi: 10.1007/s11684-010-0700-7
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 444-450 doi: 10.1007/s11684-016-0471-x
The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) has increased rapidly in recent years. However, the clinicopathological characteristics of pNENs are poorly understood. Medical records of patients who underwent surgery and were confirmed as pNENs by pathological examination from January 2003 to February 2015 in Qilu Hospital were reviewed retrospectively. A total of 100 patients, 36 males and 64 females, were included with a mean operation age of 46.26±13.41 years. Among the 100 cases, 76 had insulinomas and 24 had non-functional pNENs. Tumor size ranged from 0.5 cm to 9 cm, and the mean size was 2.20±1.40 cm. The percentages of TNM stages I, II, III, and IV tumors were 89.0%, 8.0%, 0.0%, and 3.0%, respectively. Based on the WHO classification, pNENs were classified into three grades: G1, G2, and G3. G1, G2, and G3 tumors were confirmed in 72.9%, 23.7%, and 3.4% patients, respectively. The positive rates of CgA and Syn immunohistochemical staining were 94.5% (69/73) and 100% (74/74), respectively. Compared with insulinoma, non-functional pNENs have larger tumor sizes, more advanced TNM staging, a higher Ki-67 index, and a higher rate of liver metastasis (P<0.05). In conclusion, pNENs are heterogeneous tumors with varying clinical manifestations, diverse tumor biological characteristics, and different prognoses. Non-functional pNENs present a more aggressive behavioral model and have poorer prognosis than functional pNENs.
关键词: pancreatic neuroendocrine neoplasms clinicopathological characteristic Ki-67 liver metastasis outcomes
Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects
Yongjun Chen, Renyi Qin, Xiaoping Chen
《医学前沿(英文)》 2011年 第5卷 第3期 页码 235-238 doi: 10.1007/s11684-011-0156-4
《医学前沿(英文)》 doi: 10.1007/s11684-023-1050-6
关键词: pancreatic cancer cancer screening single cell molecular alterations precancerous lesion therapy resistance
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 41-45 doi: 10.1007/s11684-007-0008-4
Total pancreatic necrosis after organophosphate intoxication
Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 285-288 doi: 10.1007/s11684-018-0626-z
关键词: organophosphate intoxication severe acute pancreatitis pancreas necrosis percutaneous catheterization sandostatin insulin
Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal
Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 91-100 doi: 10.1007/s11684-019-0696-6
关键词: HOXB9 AcK27-HOXB9 PDAC
ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng
《医学前沿(英文)》 2007年 第1卷 第1期 页码 46-48 doi: 10.1007/s11684-007-0009-3
Epidemiological study of a von Hippel-Lindau family in northwest China
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 378-385 doi: 10.1007/s11684-013-0276-0
von Hippel-Lindau (VHL) disease is a rare, inherited neoplastic disease characterized by hemangioblastomas (HBL) of the central nervous system (CNS), retinal angiomas, renal cell carcinomas (RCC), pancreatic endocrine tumors (PETs), pheochromocytomas, paragangliomas, and visceral cysts. We encountered a large VHL family in northwest China and conducted a systematic screening of the family members based on their epidemiological and clinical characteristics. A self-designed questionnaire was used to collect the general sociodemographic and health information of the family members. For the preliminary family screening, physical examination and abdomen B ultrasonography were performed. The suspected patients were subjected to cranial computerized tomography and fundus examination. The clinical data of the patients with confirmed VHL disease were collected from hospital records. A total of 63 lineal descendants in six generations were observed in the family (generations O, A, B, C, D, E), including 9 dead suspected cases (6 males, 3 females) and 10 living cases (2 males, 8 females). Among the 10 living cases, 4, 2, 1, 3, 4, 8, and 2 manifested HBLs of the CNS, PETs, RCC, pancreatic cysts, renal cysts, pheochromocytomas (4 hemi and 4 bilateral), and paragangliomas, respectively. Data showed that the morbidity of VHL disease in generation C was lower than that in generation B, but the age of onset was younger. This study is the first to report VHL disease in northwest China and VHL-associated PET cases in Chinese. Therefore, follow-up checkups of the family should be focused on younger generations. Proper family screening protocols should be followed for the treatment of patients with VHL disease.
关键词: von Hippel-Lindau disease epidemiology family screening pancreatic endocrine tumor
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 356-360 doi: 10.1007/s11684-015-0404-0
Robotic system has been increasingly used in pancreatectomy. However, the effectiveness of this method remains uncertain. This study compared the surgical outcomes between robot-assisted laparoscopic distal pancreatectomy and conventional laparoscopic distal pancreatectomy. During a 15-year period, 35 patients underwent minimally invasive approach of distal pancreatectomy in our center. Seventeen of these patients had robot-assisted laparoscopic approach, and the remaining 18 had conventional laparoscopic approach. Their operative parameters and perioperative outcomes were analyzed retrospectively in a prospective database. The mean operating time in the robotic group (221.4 min) was significantly longer than that in the laparoscopic group (173.6 min) (P = 0.026). Both robotic and conventional laparoscopic groups presented no significant difference in spleen-preservation rate (52.9% vs. 38.9%) (P = 0.505), operative blood loss (100.3 ml vs. 268.3 ml) (P = 0.29), overall morbidity rate (47.1% vs. 38.9%) (P = 0.73), and post-operative hospital stay (11.4 days vs. 14.2 days) (P = 0.46). Both groups also showed no perioperative mortality. Similar outcomes were observed in robotic distal pancreatectomy and conventional laparoscopic approach. However, robotic approach tended to have the advantages of less blood loss and shorter hospital stay. Further studies are necessary to determine the clinical position of robotic distal pancreatectomy.
关键词: distal pancreatectomy pancreatic neoplasm robotic surgery
Intracellular and extracellular TGF-β signaling in cancer: some recent topics
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《医学前沿(英文)》 2018年 第12卷 第4期 页码 387-411 doi: 10.1007/s11684-018-0646-8
Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells (Tregs). TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant (GARP, also known as leucine-rich repeat containing 32 or LRRC32). Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.
关键词: TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP
轴向零泊松比结构心血管支架的设计、3D打印与表征 Article
王程锦, 张磊, 方永聪, 孙伟
《工程(英文)》 2021年 第7卷 第7期 页码 979-990 doi: 10.1016/j.eng.2020.02.013
药物洗脱支架固有的缺陷促进了生物可吸收心血管支架的研究与发展。近年来,增材制造技术(也称3D打印技术)在医疗器械领域得到了广泛的应用。本文提出了一种新型的微螺杆挤出式3D打印系统,并利用该系统制备了一种具有零泊松比(ZPR)结构的支架。首先进行了初步的单丝挤出试验来研究合适的制造参数;随后,制备了具有不同几何结构的3D打印支架,并通过扫描电子显微镜(SEM)观察分析支架表面形貌;最后,对不同参数的3D打印支架进行了力学性能评价和初步的生物学评价。总之,基于微螺杆挤出式3D打印系统具有制备个性化支架的潜力。
标题 作者 时间 类型 操作
The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: a meta-analysis
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期刊论文
Laparoscopic surgery for pancreatic lesions: current status and future
Taiping Zhang, Xiao Du, Yupei Zhao
期刊论文
Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status
Li Jiang, Deng Ning, Xiaoping Chen
期刊论文
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
期刊论文
Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological
null
期刊论文
Laparoscopic hepato-biliary-pancreatic surgery: present practices and prospects
Yongjun Chen, Renyi Qin, Xiaoping Chen
期刊论文
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic
期刊论文
Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified
TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo
期刊论文
Total pancreatic necrosis after organophosphate intoxication
Rui Hou, Hongmin Zhang, Huan Chen, Yuankai Zhou, Yun Long, Dawei Liu
期刊论文
Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal
Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang
期刊论文
Effect of end-to-end invagination pancreaticojejunostomy with circle discontinuous U suture in pancreatic
ZHANG Xuewen, XUAN Wei, JIANG Tao, JI Degang, YANG Yongsheng, ZHANG Dan, XIE Yingjun, MENG Zihui, ZHAO Jisheng
期刊论文
Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study for short-term outcomes
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期刊论文